AEG-1–AKT2: A novel complex controlling the aggressiveness of glioblastoma

Expression of AEG-1 (also known as MTDH or LYRIC) is elevated in many cancers including glioblastoma multiforme (GBM), in which it functions as an oncogene. AEG-1 activates AKT signaling and physically interacts with AKT2 in GBM. Disruption of this interaction reduces glioma cell survival and invasi...

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Autores principales: Emdad, Luni, Hu, Bin, Das, Swadesh K, Sarkar, Devanand, Fisher, Paul B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905313/
https://www.ncbi.nlm.nih.gov/pubmed/27308476
http://dx.doi.org/10.4161/23723556.2014.995008
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author Emdad, Luni
Hu, Bin
Das, Swadesh K
Sarkar, Devanand
Fisher, Paul B
author_facet Emdad, Luni
Hu, Bin
Das, Swadesh K
Sarkar, Devanand
Fisher, Paul B
author_sort Emdad, Luni
collection PubMed
description Expression of AEG-1 (also known as MTDH or LYRIC) is elevated in many cancers including glioblastoma multiforme (GBM), in which it functions as an oncogene. AEG-1 activates AKT signaling and physically interacts with AKT2 in GBM. Disruption of this interaction reduces glioma cell survival and invasion, uncovering a novel potential target for development of an effective therapy against GBM.
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spelling pubmed-49053132016-06-15 AEG-1–AKT2: A novel complex controlling the aggressiveness of glioblastoma Emdad, Luni Hu, Bin Das, Swadesh K Sarkar, Devanand Fisher, Paul B Mol Cell Oncol Author's Views Expression of AEG-1 (also known as MTDH or LYRIC) is elevated in many cancers including glioblastoma multiforme (GBM), in which it functions as an oncogene. AEG-1 activates AKT signaling and physically interacts with AKT2 in GBM. Disruption of this interaction reduces glioma cell survival and invasion, uncovering a novel potential target for development of an effective therapy against GBM. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905313/ /pubmed/27308476 http://dx.doi.org/10.4161/23723556.2014.995008 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Emdad, Luni
Hu, Bin
Das, Swadesh K
Sarkar, Devanand
Fisher, Paul B
AEG-1–AKT2: A novel complex controlling the aggressiveness of glioblastoma
title AEG-1–AKT2: A novel complex controlling the aggressiveness of glioblastoma
title_full AEG-1–AKT2: A novel complex controlling the aggressiveness of glioblastoma
title_fullStr AEG-1–AKT2: A novel complex controlling the aggressiveness of glioblastoma
title_full_unstemmed AEG-1–AKT2: A novel complex controlling the aggressiveness of glioblastoma
title_short AEG-1–AKT2: A novel complex controlling the aggressiveness of glioblastoma
title_sort aeg-1–akt2: a novel complex controlling the aggressiveness of glioblastoma
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905313/
https://www.ncbi.nlm.nih.gov/pubmed/27308476
http://dx.doi.org/10.4161/23723556.2014.995008
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