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Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?

The system X(C)(−)/glutathione/glutathione peroxidase 4 (Gpx4) axis pivotally controls ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling evidence has established that this route of cell death is not only of high relevance for triggering cancer cell death, but a...

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Detalles Bibliográficos
Autores principales: Conrad, Marcus, Friedmann Angeli, José Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905320/
https://www.ncbi.nlm.nih.gov/pubmed/27308484
http://dx.doi.org/10.4161/23723556.2014.995047