Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?

The system X(C)(−)/glutathione/glutathione peroxidase 4 (Gpx4) axis pivotally controls ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling evidence has established that this route of cell death is not only of high relevance for triggering cancer cell death, but a...

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Detalles Bibliográficos
Autores principales: Conrad, Marcus, Friedmann Angeli, José Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905320/
https://www.ncbi.nlm.nih.gov/pubmed/27308484
http://dx.doi.org/10.4161/23723556.2014.995047
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author Conrad, Marcus
Friedmann Angeli, José Pedro
author_facet Conrad, Marcus
Friedmann Angeli, José Pedro
author_sort Conrad, Marcus
collection PubMed
description The system X(C)(−)/glutathione/glutathione peroxidase 4 (Gpx4) axis pivotally controls ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling evidence has established that this route of cell death is not only of high relevance for triggering cancer cell death, but also proves to be amenable for therapeutic intervention to halt ischemia/reperfusion-related diseases.
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spelling pubmed-49053202016-06-15 Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it? Conrad, Marcus Friedmann Angeli, José Pedro Mol Cell Oncol Author's Views The system X(C)(−)/glutathione/glutathione peroxidase 4 (Gpx4) axis pivotally controls ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling evidence has established that this route of cell death is not only of high relevance for triggering cancer cell death, but also proves to be amenable for therapeutic intervention to halt ischemia/reperfusion-related diseases. Taylor & Francis 2015-01-30 /pmc/articles/PMC4905320/ /pubmed/27308484 http://dx.doi.org/10.4161/23723556.2014.995047 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Conrad, Marcus
Friedmann Angeli, José Pedro
Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?
title Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?
title_full Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?
title_fullStr Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?
title_full_unstemmed Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?
title_short Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?
title_sort glutathione peroxidase 4 (gpx4) and ferroptosis: what's so special about it?
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905320/
https://www.ncbi.nlm.nih.gov/pubmed/27308484
http://dx.doi.org/10.4161/23723556.2014.995047
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