The life history of neochromosomes revealed

Neochromosomes are a little-studied class of chromosome-scale mutations that drive some cancers. By sequencing isolated neochromosomes from liposarcomas, we recently defined their structure at single-nucleotide resolution and proposed a model for their life history. Here, we summarize that work, hig...

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Detalles Bibliográficos
Autores principales: Papenfuss, Anthony T, Thomas, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905327/
https://www.ncbi.nlm.nih.gov/pubmed/27308490
http://dx.doi.org/10.1080/23723556.2014.1000698
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author Papenfuss, Anthony T
Thomas, David M
author_facet Papenfuss, Anthony T
Thomas, David M
author_sort Papenfuss, Anthony T
collection PubMed
description Neochromosomes are a little-studied class of chromosome-scale mutations that drive some cancers. By sequencing isolated neochromosomes from liposarcomas, we recently defined their structure at single-nucleotide resolution and proposed a model for their life history. Here, we summarize that work, highlighting significant aspects and providing historical context and insight into the discovery process.
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spelling pubmed-49053272016-06-15 The life history of neochromosomes revealed Papenfuss, Anthony T Thomas, David M Mol Cell Oncol Author's View Neochromosomes are a little-studied class of chromosome-scale mutations that drive some cancers. By sequencing isolated neochromosomes from liposarcomas, we recently defined their structure at single-nucleotide resolution and proposed a model for their life history. Here, we summarize that work, highlighting significant aspects and providing historical context and insight into the discovery process. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905327/ /pubmed/27308490 http://dx.doi.org/10.1080/23723556.2014.1000698 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Papenfuss, Anthony T
Thomas, David M
The life history of neochromosomes revealed
title The life history of neochromosomes revealed
title_full The life history of neochromosomes revealed
title_fullStr The life history of neochromosomes revealed
title_full_unstemmed The life history of neochromosomes revealed
title_short The life history of neochromosomes revealed
title_sort life history of neochromosomes revealed
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905327/
https://www.ncbi.nlm.nih.gov/pubmed/27308490
http://dx.doi.org/10.1080/23723556.2014.1000698
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