YAP enters the mTOR pathway to promote tuberous sclerosis complex

Mutations in tuberous sclerosis complex 1 (TSC1) or TSC2 predispose to angiomyolipomas and lymphangioleiomyomatosis in a mTOR-dependent manner. In these mesenchymal lesions, mTOR suppresses macroautophagy-mediated lysosomal degradation of YAP, which is a transcriptional coactivator of Hippo pathway...

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Detalles Bibliográficos
Autores principales: Liang, Ning, Pende, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905364/
https://www.ncbi.nlm.nih.gov/pubmed/27308518
http://dx.doi.org/10.1080/23723556.2014.998100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905364/
https://www.ncbi.nlm.nih.gov/pubmed/27308518
http://dx.doi.org/10.1080/23723556.2014.998100

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