Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer

Acquired resistance to Hedgehog pathway inhibitors has been reported in the clinical setting and upregulation of noncanonical Hedgehog signaling is one of the major underlying mechanisms behind this resistance. As demonstrated in our recent study, greater clinical efficacy might be achieved by focus...

Descripción completa

Detalles Bibliográficos
Autores principales: Xing, Zhen, Lin, Chunru, Yang, Liuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905365/
https://www.ncbi.nlm.nih.gov/pubmed/27308519
http://dx.doi.org/10.1080/23723556.2014.998900
Descripción
Sumario:Acquired resistance to Hedgehog pathway inhibitors has been reported in the clinical setting and upregulation of noncanonical Hedgehog signaling is one of the major underlying mechanisms behind this resistance. As demonstrated in our recent study, greater clinical efficacy might be achieved by focusing on downstream targets of the chemokine-activated noncanonical Hedgehog signaling pathway such as BCAR4 and phospho-GLI2 (Ser149).

Ejemplares similares