Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer

Acquired resistance to Hedgehog pathway inhibitors has been reported in the clinical setting and upregulation of noncanonical Hedgehog signaling is one of the major underlying mechanisms behind this resistance. As demonstrated in our recent study, greater clinical efficacy might be achieved by focus...

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Detalles Bibliográficos
Autores principales: Xing, Zhen, Lin, Chunru, Yang, Liuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905365/
https://www.ncbi.nlm.nih.gov/pubmed/27308519
http://dx.doi.org/10.1080/23723556.2014.998900
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author Xing, Zhen
Lin, Chunru
Yang, Liuqing
author_facet Xing, Zhen
Lin, Chunru
Yang, Liuqing
author_sort Xing, Zhen
collection PubMed
description Acquired resistance to Hedgehog pathway inhibitors has been reported in the clinical setting and upregulation of noncanonical Hedgehog signaling is one of the major underlying mechanisms behind this resistance. As demonstrated in our recent study, greater clinical efficacy might be achieved by focusing on downstream targets of the chemokine-activated noncanonical Hedgehog signaling pathway such as BCAR4 and phospho-GLI2 (Ser149).
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spelling pubmed-49053652016-06-15 Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer Xing, Zhen Lin, Chunru Yang, Liuqing Mol Cell Oncol Author's View Acquired resistance to Hedgehog pathway inhibitors has been reported in the clinical setting and upregulation of noncanonical Hedgehog signaling is one of the major underlying mechanisms behind this resistance. As demonstrated in our recent study, greater clinical efficacy might be achieved by focusing on downstream targets of the chemokine-activated noncanonical Hedgehog signaling pathway such as BCAR4 and phospho-GLI2 (Ser149). Taylor & Francis 2015-01-23 /pmc/articles/PMC4905365/ /pubmed/27308519 http://dx.doi.org/10.1080/23723556.2014.998900 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Xing, Zhen
Lin, Chunru
Yang, Liuqing
Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer
title Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer
title_full Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer
title_fullStr Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer
title_full_unstemmed Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer
title_short Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer
title_sort unraveling the therapeutic potential of the lncrna-dependent noncanonical hedgehog pathway in cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905365/
https://www.ncbi.nlm.nih.gov/pubmed/27308519
http://dx.doi.org/10.1080/23723556.2014.998900
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