HIF-1 suppresses lipid catabolism to promote cancer progression

Hypoxia-inducible factor 1 (HIF-1) promotes glycolysis in cancer cells, hence sustaining survival. We recently reported that HIF-1 suppresses fatty acid β-oxidation in malignant cells through medium- and long-chain acyl-CoA dehydrogenases. This promotes tumor progression by controlling the level of...

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Detalles Bibliográficos
Autor principal: Zhang, Huafeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905416/
https://www.ncbi.nlm.nih.gov/pubmed/27308514
http://dx.doi.org/10.4161/23723556.2014.980184
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author Zhang, Huafeng
author_facet Zhang, Huafeng
author_sort Zhang, Huafeng
collection PubMed
description Hypoxia-inducible factor 1 (HIF-1) promotes glycolysis in cancer cells, hence sustaining survival. We recently reported that HIF-1 suppresses fatty acid β-oxidation in malignant cells through medium- and long-chain acyl-CoA dehydrogenases. This promotes tumor progression by controlling the level of reactive oxygen species and via crosstalk between metabolism and PTEN signaling.
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spelling pubmed-49054162016-07-07 HIF-1 suppresses lipid catabolism to promote cancer progression Zhang, Huafeng Mol Cell Oncol Author's View Hypoxia-inducible factor 1 (HIF-1) promotes glycolysis in cancer cells, hence sustaining survival. We recently reported that HIF-1 suppresses fatty acid β-oxidation in malignant cells through medium- and long-chain acyl-CoA dehydrogenases. This promotes tumor progression by controlling the level of reactive oxygen species and via crosstalk between metabolism and PTEN signaling. Taylor & Francis 2015-07-07 /pmc/articles/PMC4905416/ /pubmed/27308514 http://dx.doi.org/10.4161/23723556.2014.980184 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Zhang, Huafeng
HIF-1 suppresses lipid catabolism to promote cancer progression
title HIF-1 suppresses lipid catabolism to promote cancer progression
title_full HIF-1 suppresses lipid catabolism to promote cancer progression
title_fullStr HIF-1 suppresses lipid catabolism to promote cancer progression
title_full_unstemmed HIF-1 suppresses lipid catabolism to promote cancer progression
title_short HIF-1 suppresses lipid catabolism to promote cancer progression
title_sort hif-1 suppresses lipid catabolism to promote cancer progression
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905416/
https://www.ncbi.nlm.nih.gov/pubmed/27308514
http://dx.doi.org/10.4161/23723556.2014.980184
work_keys_str_mv AT zhanghuafeng hif1suppresseslipidcatabolismtopromotecancerprogression

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