Melanoma metastases caught in the AKT

Dysregulated protein kinase B alpha (PKB/AKT1) signaling has been increasingly implicated in melanoma metastasis to distant organs, especially the brain. In a recent study, we expressed activated AKT1 in a non-metastatic melanoma model in vivo and discovered that AKT1 activation decreased tumor late...

Descripción completa

Detalles Bibliográficos
Autores principales: Kircher, David A., Arave, Rowan A., Cho, Joseph H., Holmen, Sheri L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905423/
https://www.ncbi.nlm.nih.gov/pubmed/27308635
http://dx.doi.org/10.1080/23723556.2015.1128516
_version_ 1782437257530048512
author Kircher, David A.
Arave, Rowan A.
Cho, Joseph H.
Holmen, Sheri L.
author_facet Kircher, David A.
Arave, Rowan A.
Cho, Joseph H.
Holmen, Sheri L.
author_sort Kircher, David A.
collection PubMed
description Dysregulated protein kinase B alpha (PKB/AKT1) signaling has been increasingly implicated in melanoma metastasis to distant organs, especially the brain. In a recent study, we expressed activated AKT1 in a non-metastatic melanoma model in vivo and discovered that AKT1 activation decreased tumor latency and elicited lung and brain metastases in this context.
format Online
Article
Text
id pubmed-4905423
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-49054232017-02-18 Melanoma metastases caught in the AKT Kircher, David A. Arave, Rowan A. Cho, Joseph H. Holmen, Sheri L. Mol Cell Oncol Author's View Dysregulated protein kinase B alpha (PKB/AKT1) signaling has been increasingly implicated in melanoma metastasis to distant organs, especially the brain. In a recent study, we expressed activated AKT1 in a non-metastatic melanoma model in vivo and discovered that AKT1 activation decreased tumor latency and elicited lung and brain metastases in this context. Taylor & Francis 2016-02-18 /pmc/articles/PMC4905423/ /pubmed/27308635 http://dx.doi.org/10.1080/23723556.2015.1128516 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Kircher, David A.
Arave, Rowan A.
Cho, Joseph H.
Holmen, Sheri L.
Melanoma metastases caught in the AKT
title Melanoma metastases caught in the AKT
title_full Melanoma metastases caught in the AKT
title_fullStr Melanoma metastases caught in the AKT
title_full_unstemmed Melanoma metastases caught in the AKT
title_short Melanoma metastases caught in the AKT
title_sort melanoma metastases caught in the akt
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905423/
https://www.ncbi.nlm.nih.gov/pubmed/27308635
http://dx.doi.org/10.1080/23723556.2015.1128516
work_keys_str_mv AT kircherdavida melanomametastasescaughtintheakt
AT araverowana melanomametastasescaughtintheakt
AT chojosephh melanomametastasescaughtintheakt
AT holmensheril melanomametastasescaughtintheakt

Ejemplares similares