A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA(+) oral cancers

mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the activity of targeted agents. Thus, co-targetin...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamaguchi, Kosuke, Iglesias-Bartolomé, Ramiro, Wang, Zhiyong, Callejas-Valera, Juan Luis, Amornphimoltham, Panomwat, Molinolo, Alfredo A., Cohen, Ezra E., Califano, Joseph A., Lippman, Scott M., Luo, Ji, Gutkind, J. Silvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905432/
https://www.ncbi.nlm.nih.gov/pubmed/26882569
http://dx.doi.org/10.18632/oncotarget.7372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905432/
https://www.ncbi.nlm.nih.gov/pubmed/26882569
http://dx.doi.org/10.18632/oncotarget.7372

Ejemplares similares