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Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling

It is suggested that oxLDL is decisive in the initiation and development of atherosclerotic injuries. The up-regulation of oxidative stress and the generation of ROS act as key modulators in developing pro-atherosclerotic and anti-atherosclerotic processes in the human endothelial wall. In this pres...

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Detalles Bibliográficos
Autores principales:	Hung, Ching-Hsia, Chan, Shih-Hung, Chu, Pei-Ming, Lin, Huei-Chen, Tsai, Kun-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905438/ https://www.ncbi.nlm.nih.gov/pubmed/26885898 http://dx.doi.org/10.18632/oncotarget.7387

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