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Identification of quinazoline compounds as novel potent inhibitors of Wnt/β-catenin signaling in colorectal cancer cells

The Wnt/β-catenin signaling pathway is critical for the initiation and progression of most colon cancers, and has emerged as one of the most promising targets for colorectal cancer chemoprevention and treatment. In this study, we have discovered a structurally related series of quinazolines as poten...

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Detalles Bibliográficos
Autores principales: Li, Yonghe, Lu, Wenyan, Saini, Surendra K., Moukha-Chafiq, Omar, Pathak, Vibha, Ananthan, Subramaniam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905471/
https://www.ncbi.nlm.nih.gov/pubmed/26820295
http://dx.doi.org/10.18632/oncotarget.7019