Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines

One of the hallmarks of cancer is a resistance to the induction of programmed cell death that is mediated by selection of cells with elevated expression of anti-apoptotic members of the BCL-2 family. To counter this resistance, new therapeutic agents known as BH3-mimetic small molecules are in devel...

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Detalles Bibliográficos
Autores principales: Koss, Brian, Ryan, Jeremy, Budhraja, Amit, Szarama, Katherine, Yang, Xue, Bathina, Madhavi, Cardone, Michael H., Nikolovska-Coleska, Zaneta, Letai, Anthony, Opferman, Joseph T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905489/
https://www.ncbi.nlm.nih.gov/pubmed/26862853
http://dx.doi.org/10.18632/oncotarget.7204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905489/
https://www.ncbi.nlm.nih.gov/pubmed/26862853
http://dx.doi.org/10.18632/oncotarget.7204

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