Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport

Pirinixic acid derivatives, a new class of drug candidates for a range of diseases, interfere with targets including PPARα, PPARγ, 5-lipoxygenase (5-LO), and microsomal prostaglandin and E2 synthase-1 (mPGES1). Since 5-LO, mPGES1, PPARα, and PPARγ represent potential anti-cancer drug targets, we her...

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Detalles Bibliográficos
Autores principales: Michaelis, Martin, Rothweiler, Florian, Wurglics, Mario, Aniceto, Natália, Dittrich, Michaela, Zettl, Heiko, Wiese, Michael, Wass, Mark, Ghafourian, Taravat, Schubert-Zsilavecz, Manfred, Cinatl, Jindrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905501/
https://www.ncbi.nlm.nih.gov/pubmed/26887049
http://dx.doi.org/10.18632/oncotarget.7345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905501/
https://www.ncbi.nlm.nih.gov/pubmed/26887049
http://dx.doi.org/10.18632/oncotarget.7345

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