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Glucocorticoids Induce Nondipping Blood Pressure by Activating the Thiazide-Sensitive Cotransporter

Blood pressure (BP) normally dips during sleep, and nondipping increases cardiovascular risk. Hydrochlorothiazide restores the dipping BP profile in nondipping patients, suggesting that the NaCl cotransporter, NCC, is an important determinant of daily BP variation. NCC activity in cells is regulated...

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Detalles Bibliográficos
Autores principales: Ivy, Jessica R., Oosthuyzen, Wilna, Peltz, Theresa S., Howarth, Amelia R., Hunter, Robert W., Dhaun, Neeraj, Al-Dujaili, Emad A.S., Webb, David J., Dear, James W., Flatman, Peter W., Bailey, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott, Williams & Wilkins 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905621/
https://www.ncbi.nlm.nih.gov/pubmed/26953322
http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06977