XTEN as Biological Alternative to PEGylation Allows Complete Expression of a Protease-Activatable Killin-Based Cytostatic

Increased effectiveness and reduced side effects are general goals in drug research, especially important in cancer therapy. The aim of this study was to design a long-circulating, activatable cytostatic drug that is completely producible in E. coli. Crucial for this goal was the novel unstructured...

Descripción completa

Detalles Bibliográficos
Autores principales: Haeckel, Akvile, Appler, Franziska, Ariza de Schellenberger, Angela, Schellenberger, Eyk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905650/
https://www.ncbi.nlm.nih.gov/pubmed/27295081
http://dx.doi.org/10.1371/journal.pone.0157193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905650/
https://www.ncbi.nlm.nih.gov/pubmed/27295081
http://dx.doi.org/10.1371/journal.pone.0157193

Ejemplares similares