ABCC4 Is a Determinant of Cytarabine‐Induced Cytotoxicity and Myelosuppression

Resistance to cytarabine remains a major challenge in the treatment of acute myeloid leukemia (AML). Based on previous studies implicating ABCC4/MRP4 in the transport of nucleosides, we hypothesized that cytarabine is sensitive to ABCC4‐mediated efflux, thereby decreasing its cytotoxic response agai...

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Detalles Bibliográficos
Autores principales: Drenberg, CD, Hu, S, Li, L, Buelow, DR, Orwick, SJ, Gibson, AA, Schuetz, JD, Sparreboom, A, Baker, SD
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905720/
https://www.ncbi.nlm.nih.gov/pubmed/26842729
http://dx.doi.org/10.1111/cts.12366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905720/
https://www.ncbi.nlm.nih.gov/pubmed/26842729
http://dx.doi.org/10.1111/cts.12366

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