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ABCC4 Is a Determinant of Cytarabine‐Induced Cytotoxicity and Myelosuppression

Resistance to cytarabine remains a major challenge in the treatment of acute myeloid leukemia (AML). Based on previous studies implicating ABCC4/MRP4 in the transport of nucleosides, we hypothesized that cytarabine is sensitive to ABCC4‐mediated efflux, thereby decreasing its cytotoxic response agai...

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Detalles Bibliográficos
Autores principales:	Drenberg, CD, Hu, S, Li, L, Buelow, DR, Orwick, SJ, Gibson, AA, Schuetz, JD, Sparreboom, A, Baker, SD
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905720/ https://www.ncbi.nlm.nih.gov/pubmed/26842729 http://dx.doi.org/10.1111/cts.12366

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