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Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance

Successful reconstitution of cytomegalovirus (CMV)-specific CD8(+) T cells by hematopoietic cell transplantation (HCT) gives a favorable prognosis for the control of CMV reactivation and prevention of CMV disease after hematoablative therapy of hematopoietic malignancies. In the transient immunocomp...

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Detalles Bibliográficos
Autores principales: Holtappels, Rafaela, Lemmermann, Niels A. W., Podlech, Jürgen, Ebert, Stefan, Reddehase, Matthias J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905951/
https://www.ncbi.nlm.nih.gov/pubmed/27379095
http://dx.doi.org/10.3389/fimmu.2016.00232