Cargando…

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance

Successful reconstitution of cytomegalovirus (CMV)-specific CD8(+) T cells by hematopoietic cell transplantation (HCT) gives a favorable prognosis for the control of CMV reactivation and prevention of CMV disease after hematoablative therapy of hematopoietic malignancies. In the transient immunocomp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holtappels, Rafaela, Lemmermann, Niels A. W., Podlech, Jürgen, Ebert, Stefan, Reddehase, Matthias J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905951/ https://www.ncbi.nlm.nih.gov/pubmed/27379095 http://dx.doi.org/10.3389/fimmu.2016.00232

Ejemplares similares

Immunodominant Cytomegalovirus Epitopes Suppress Subdominant Epitopes in the Generation of High-Avidity CD8 T Cells
por: Freitag, Kirsten, et al.
Publicado: (2021)

Memory CD8 T Cells Protect against Cytomegalovirus Disease by Formation of Nodular Inflammatory Foci Preventing Intra-Tissue Virus Spread
por: Holtappels, Rafaela, et al.
Publicado: (2022)

Therapeutic Vaccination of Hematopoietic Cell Transplantation Recipients Improves Protective CD8 T-Cell Immunotherapy of Cytomegalovirus Infection
por: Gergely, Kerstin M., et al.
Publicado: (2021)

Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells
por: Holtappels, Rafaela, et al.
Publicado: (2023)

Consequence of Histoincompatibility beyond GvH-Reaction in Cytomegalovirus Disease Associated with Allogeneic Hematopoietic Cell Transplantation: Change of Paradigm
por: Reddehase, Matthias J., et al.
Publicado: (2021)

Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation
por: Holtappels, Rafaela, et al.
Publicado: (2020)

Noncanonical Expression of a Murine Cytomegalovirus Early Protein CD8 T-Cell Epitope as an Immediate Early Epitope Based on Transcription from an Upstream Gene
por: Fink, Annette, et al.
Publicado: (2014)

Cytomegalovirus Misleads Its Host by Priming of CD8 T Cells Specific for an Epitope Not Presented in Infected Tissues
por: Holtappels, Rafaela, et al.
Publicado: (2004)

Mast Cells Expedite Control of Pulmonary Murine Cytomegalovirus Infection by Enhancing the Recruitment of Protective CD8 T Cells to the Lungs
por: Ebert, Stefan, et al.
Publicado: (2014)

Revisiting CD8 T-cell ‘Memory Inflation’: New Insights with Implications for Cytomegaloviruses as Vaccine Vectors
por: Holtappels, Rafaela, et al.
Publicado: (2020)

Cytomegalovirus-Associated Inhibition of Hematopoiesis Is Preventable by Cytoimmunotherapy With Antiviral CD8 T Cells
por: Renzaho, Angelique, et al.
Publicado: (2020)

Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation
por: Gezinir, Emin, et al.
Publicado: (2020)

Host-Adapted Gene Families Involved in Murine Cytomegalovirus Immune Evasion
por: Becker, Sara, et al.
Publicado: (2022)

Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells
por: Reuter, Sebastian, et al.
Publicado: (2019)

Cytomegalovirus immune evasion sets the functional avidity threshold for protection by CD8 T cells
por: Hamdan, Sara, et al.
Publicado: (2022)

Localization of Viral Epitope-Specific CD8 T Cells during Cytomegalovirus Latency in the Lungs and Recruitment to Lung Parenchyma by Airway Challenge Infection
por: Blaum, Franziska, et al.
Publicado: (2021)

Reverse Genetics Modification of Cytomegalovirus Antigenicity and Immunogenicity by CD8 T-Cell Epitope Deletion and Insertion
por: Lemmermann, Niels A. W., et al.
Publicado: (2011)

Mutual Interference between Cytomegalovirus and Reconstitution of Protective Immunity after Hematopoietic Cell Transplantation
por: Reddehase, Matthias J.
Publicado: (2016)

Positive Role of the MHC Class-I Antigen Presentation Regulator m04/gp34 of Murine Cytomegalovirus in Antiviral Protection by CD8 T Cells
por: Becker, Sara, et al.
Publicado: (2020)

Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice
por: Thomas, Simone, et al.
Publicado: (2015)

Mast Cells Meet Cytomegalovirus: A New Example of Protective Mast Cell Involvement in an Infectious Disease
por: Becker, Sara, et al.
Publicado: (2022)

Direct Evidence for Viral Antigen Presentation during Latent Cytomegalovirus Infection
por: Lemmermann, Niels A. W., et al.
Publicado: (2021)

Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions for Medical Translation that Survived the “Test of Time”
por: Reddehase, Matthias J., et al.
Publicado: (2018)

Stochastic Episodes of Latent Cytomegalovirus Transcription Drive CD8 T-Cell “Memory Inflation” and Avoid Immune Evasion
por: Griessl, Marion, et al.
Publicado: (2021)

Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion
por: Ameres, Stefanie, et al.
Publicado: (2013)

Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
por: Lemmermann, Niels A. W., et al.
Publicado: (2015)

The p36 Isoform of Murine Cytomegalovirus m152 Protein Suffices for Mediating Innate and Adaptive Immune Evasion
por: Fink, Annette, et al.
Publicado: (2013)

The Anti-apoptotic Murine Cytomegalovirus Protein vMIA-m38.5 Induces Mast Cell Degranulation
por: Schmiedeke, Julia K., et al.
Publicado: (2020)

Major Histocompatibility Complex Class I Allele-specific Cooperative and Competitive Interactions between Immune Evasion Proteins of Cytomegalovirus
por: Wagner, Markus, et al.
Publicado: (2002)

Shedding Light on the Elusive Role of Endothelial Cells in Cytomegalovirus Dissemination
por: Sacher, Torsten, et al.
Publicado: (2011)

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription
por: Chan, Baca, et al.
Publicado: (2017)

Immunodominant cytomegalovirus-specific CD8+ T-cell responses in sub-Saharan African populations
por: Malik, Amna, et al.
Publicado: (2017)

Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance
por: Rosendahl Huber, Sietske K., et al.
Publicado: (2016)

Dm Determines the Cryptic and Immunodominant Fate of T Cell Epitopes
por: Nanda, Navreet K., et al.
Publicado: (2000)

The Relative Positioning of B and T Cell Epitopes Drives Immunodominance
por: Biavasco, Riccardo, et al.
Publicado: (2022)

The Viral Chemokine MCK-2 of Murine Cytomegalovirus Promotes Infection as Part of a gH/gL/MCK-2 Complex
por: Wagner, Felicia M., et al.
Publicado: (2013)

Polyfunctional CD4(+) T Cell Responses to Immunodominant Epitopes Correlate with Disease Activity of Virulent Salmonella
por: Maybeno, Matt, et al.
Publicado: (2012)

Broad TCR Repertoire And Diverse Structural Solutions To Recognition Of An Immunodominant CD8 T Cell Epitope
por: Song, InYoung, et al.
Publicado: (2017)

Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants
por: Meyer, Saskia, et al.
Publicado: (2023)

Mapping Immunodominant Antibody Epitopes of Abrin
por: Alcalay, Ron, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_va746sblms1dsum03rhucnhlf4