Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor

Glycine receptors (GlyRs) mediate inhibitory neurotransmission and are targets for alcohols and anesthetics in brain. GlyR transmembrane (TM) domains contain critical residues for alcohol/anesthetic action: amino acid A288 in TM3 forms crosslinks with TM1 (I229) in the adjacent subunit as well as TM...

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Detalles Bibliográficos
Autores principales: McCracken, Mandy L., Gorini, Giorgio, McCracken, Lindsay M., Mayfield, R. Dayne, Harris, R. Adron, Trudell, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906044/
https://www.ncbi.nlm.nih.gov/pubmed/27378846
http://dx.doi.org/10.3389/fnmol.2016.00045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906044/
https://www.ncbi.nlm.nih.gov/pubmed/27378846
http://dx.doi.org/10.3389/fnmol.2016.00045

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