Cargando…

The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

Forms of Parkinson's disease (PD) are associated with lysosomal and autophagic dysfunction. ATP13A2, which is mutated in some types of early-onset Parkinsonism, has been suggested as a regulator of the autophagy–lysosome pathway. However, little is known about the ATP13A2 effectors and how they...

Descripción completa

Detalles Bibliográficos
Autores principales: Bento, Carla F., Ashkenazi, Avraham, Jimenez-Sanchez, Maria, Rubinsztein, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906231/
https://www.ncbi.nlm.nih.gov/pubmed/27278822
http://dx.doi.org/10.1038/ncomms11803