Stimulation of Synaptic Vesicle Exocytosis by the Mental Disease Gene DISC1 is Mediated by N-Type Voltage-Gated Calcium Channels

Lesions and mutations of the DISC1 (Disrupted-in-schizophrenia-1) gene have been linked to major depression, schizophrenia, bipolar disorder and autism, but the influence of DISC1 on synaptic transmission remains poorly understood. Using two independent genetic approaches—RNAi and a DISC1 KO mouse—w...

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Detalles Bibliográficos
Autores principales: Tang, Willcyn, Thevathasan, Jervis Vermal, Lin, Qingshu, Lim, Kim Buay, Kuroda, Keisuke, Kaibuchi, Kozo, Bilger, Marcel, Soong, Tuck Wah, Fivaz, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906242/
https://www.ncbi.nlm.nih.gov/pubmed/27378904
http://dx.doi.org/10.3389/fnsyn.2016.00015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906242/
https://www.ncbi.nlm.nih.gov/pubmed/27378904
http://dx.doi.org/10.3389/fnsyn.2016.00015

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