A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis...

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Detalles Bibliográficos
Autores principales: Poh, Jian-Siang, Browne, Duncan L., Ley, Steven V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906367/
https://www.ncbi.nlm.nih.gov/pubmed/27398231
http://dx.doi.org/10.1039/c5re00082c
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author Poh, Jian-Siang
Browne, Duncan L.
Ley, Steven V.
author_facet Poh, Jian-Siang
Browne, Duncan L.
Ley, Steven V.
author_sort Poh, Jian-Siang
collection PubMed
description A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target.
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spelling pubmed-49063672016-07-06 A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process Poh, Jian-Siang Browne, Duncan L. Ley, Steven V. React Chem Eng Chemistry A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target. Royal Society of Chemistry 2016-02-03 2016-01-07 /pmc/articles/PMC4906367/ /pubmed/27398231 http://dx.doi.org/10.1039/c5re00082c Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Poh, Jian-Siang
Browne, Duncan L.
Ley, Steven V.
A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
title A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
title_full A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
title_fullStr A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
title_full_unstemmed A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
title_short A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
title_sort multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906367/
https://www.ncbi.nlm.nih.gov/pubmed/27398231
http://dx.doi.org/10.1039/c5re00082c
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