In Silico Modeling of Liver Metabolism in a Human Disease Reveals a Key Enzyme for Histidine and Histamine Homeostasis

Primary hyperoxaluria type I (PH1) is an autosomal-recessive inborn error of liver metabolism caused by alanine:glyoxylate aminotransferase (AGT) deficiency. In silico modeling of liver metabolism in PH1 recapitulated accumulation of known biomarkers as well as alteration of histidine and histamine...

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Detalles Bibliográficos
Autores principales: Pagliarini, Roberto, Castello, Raffaele, Napolitano, Francesco, Borzone, Roberta, Annunziata, Patrizia, Mandrile, Giorgia, De Marchi, Mario, Brunetti-Pierri, Nicola, di Bernardo, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906368/
https://www.ncbi.nlm.nih.gov/pubmed/27239044
http://dx.doi.org/10.1016/j.celrep.2016.05.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906368/
https://www.ncbi.nlm.nih.gov/pubmed/27239044
http://dx.doi.org/10.1016/j.celrep.2016.05.014

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