Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation

Despite major recent advances in C–H activation, discrimination between two similar, unactivated C–H positions is beyond the scope of current chemocatalytic methods. Here we demonstrate that integration of regioselective halogenase enzymes with Pd-catalysed cross-coupling chemistry, in one-pot react...

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Detalles Bibliográficos
Autores principales: Latham, Jonathan, Henry, Jean-Marc, Sharif, Humera H., Menon, Binuraj R. K., Shepherd, Sarah A., Greaney, Michael F., Micklefield, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906404/
https://www.ncbi.nlm.nih.gov/pubmed/27283121
http://dx.doi.org/10.1038/ncomms11873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906404/
https://www.ncbi.nlm.nih.gov/pubmed/27283121
http://dx.doi.org/10.1038/ncomms11873

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