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Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway
Autophagy is the main homeostatic pathway guiding cytosolic materials for degradation by the lysosome. Maturation of autophagosomes requires their transport towards the perinuclear region of the cell, with key factors underlying both processes still poorly understood. Here we show that transport and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906411/ https://www.ncbi.nlm.nih.gov/pubmed/27283760 http://dx.doi.org/10.1038/ncomms11808 |