Pharmacological inhibition of PI3K class III enhances the production of pro- and anti-inflammatory cytokines in dendritic cells stimulated by TLR agonists

The phosphatidylinositol 3-kinase (PI3K) pathway is known to down-regulate inflammatory cytokine responses in dendritic cells and macrophages stimulated with TLR agonists. This is due to class I PI3Ks causing the activation of Akt, which in turn inactivates GSK3, a kinase that promotes the transcrip...

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Detalles Bibliográficos
Autores principales: Pittini, Álvaro, Casaravilla, Cecilia, Allen, Judith E., Díaz, Álvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907315/
https://www.ncbi.nlm.nih.gov/pubmed/27168056
http://dx.doi.org/10.1016/j.intimp.2016.04.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907315/
https://www.ncbi.nlm.nih.gov/pubmed/27168056
http://dx.doi.org/10.1016/j.intimp.2016.04.028

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