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Pharmacological inhibition of PI3K class III enhances the production of pro- and anti-inflammatory cytokines in dendritic cells stimulated by TLR agonists
The phosphatidylinositol 3-kinase (PI3K) pathway is known to down-regulate inflammatory cytokine responses in dendritic cells and macrophages stimulated with TLR agonists. This is due to class I PI3Ks causing the activation of Akt, which in turn inactivates GSK3, a kinase that promotes the transcrip...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907315/ https://www.ncbi.nlm.nih.gov/pubmed/27168056 http://dx.doi.org/10.1016/j.intimp.2016.04.028 |