Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4–MD2 Complex

Background. Single inhibition of the Toll-like receptor 4 (TLR4)–MD2 complex failed in treatment of sepsis. CD14 is a coreceptor for several TLRs, including TLR4 and TLR2. The aim of this study was to investigate the effect of single TLR4-MD2 inhibition by using eritoran, compared with the effect of...

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Detalles Bibliográficos
Autores principales: Gustavsen, Alice, Nymo, Stig, Landsem, Anne, Christiansen, Dorte, Ryan, Liv, Husebye, Harald, Lau, Corinna, Pischke, Søren E., Lambris, John D., Espevik, Terje, Mollnes, Tom E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907417/
https://www.ncbi.nlm.nih.gov/pubmed/26977050
http://dx.doi.org/10.1093/infdis/jiw100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907417/
https://www.ncbi.nlm.nih.gov/pubmed/26977050
http://dx.doi.org/10.1093/infdis/jiw100

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