Cargando…

Erythropoietin Slows Photoreceptor Cell Death in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

PURPOSE: To test the efficacy of systemic gene delivery of a mutant form of erythropoietin (EPO-R76E) that has attenuated erythropoietic activity, in a mouse model of autosomal dominant retinitis pigmentosa. METHODS: Ten-day old mice carrying one copy of human rhodopsin with the P23H mutation and bo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rex, Tonia S., Kasmala, Lorraine, Bond, Wesley S., de Lucas Cerrillo, Ana M., Wynn, Kristi, Lewin, Alfred S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907422/ https://www.ncbi.nlm.nih.gov/pubmed/27299810 http://dx.doi.org/10.1371/journal.pone.0157411

Ejemplares similares

Gene Therapy for Rhodopsin-associated Autosomal Dominant Retinitis Pigmentosa
por: Massengill, Michael T., et al.
Publicado: (2021)

Gene therapy in animal models of autosomal dominant retinitis pigmentosa
por: Rossmiller, Brian, et al.
Publicado: (2012)

Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa
por: Massengill, Michael T., et al.
Publicado: (2020)

Safety and angiogenic effects of systemic gene delivery of a modified erythropoietin
por: de Lucas Cerrillo, Ana, et al.
Publicado: (2015)

SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa
por: Ahmed, Chulbul M., et al.
Publicado: (2019)

SPP2 Mutations Cause Autosomal Dominant Retinitis Pigmentosa
por: Liu, Yuan, et al.
Publicado: (2015)

SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa
por: Zhang, Tao, et al.
Publicado: (2021)

Evidence That Erythropoietin Modulates Neuroinflammation through Differential Action on Neurons, Astrocytes, and Microglia
por: Bond, Wesley S., et al.
Publicado: (2014)

Mutations in the TOPORS gene cause 1% of autosomal dominant retinitis pigmentosa
por: Bowne, Sara J., et al.
Publicado: (2008)

Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa
por: Massengill, Michael T., et al.
Publicado: (2018)

Genotyping microarray: Mutation screening in Spanish families with autosomal dominant retinitis pigmentosa
por: Blanco-Kelly, Fiona, et al.
Publicado: (2012)

Mutational screening of splicing factor genes in cases with autosomal dominant retinitis pigmentosa
por: Benaglio, Paola, et al.
Publicado: (2014)

Two novel mutations in PRPF3 causing autosomal dominant retinitis pigmentosa
por: Zhong, Zilin, et al.
Publicado: (2016)

Myriocin Effect on Tvrm4 Retina, an Autosomal Dominant Pattern of Retinitis Pigmentosa
por: Piano, Ilaria, et al.
Publicado: (2020)

Pharmacological strategies for treating misfolded rhodopsin-associated autosomal dominant retinitis pigmentosa
por: Xi, Yibo, et al.
Publicado: (2021)

Mechanisms of Photoreceptor Death in Retinitis Pigmentosa
por: Newton, Fay, et al.
Publicado: (2020)

Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa
por: Millington-Ward, Sophia, et al.
Publicado: (2011)

Identification of the Photoreceptor Transcriptional Co-Repressor SAMD11 as Novel Cause of Autosomal Recessive Retinitis Pigmentosa
por: Corton, M., et al.
Publicado: (2016)

Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa
por: Bhootada, Yogesh, et al.
Publicado: (2016)

Complexity of the Class B Phenotype in Autosomal Dominant Retinitis Pigmentosa Due to Rhodopsin Mutations
por: Jacobson, Samuel G., et al.
Publicado: (2016)

Novel PRPF31 mutations associated with Chinese autosomal dominant retinitis pigmentosa patients
por: Xu, Fei, et al.
Publicado: (2012)

Corrigendum: Two novel mutations in PRPF3 causing autosomal dominant retinitis pigmentosa
por: Zhong, Zilin, et al.
Publicado: (2017)

Novel disease-causing variant in RDH12 presenting with autosomal dominant retinitis pigmentosa
por: Muthiah, Manickam Nick, et al.
Publicado: (2022)

Restoration of Cone Photoreceptor Function in Retinitis Pigmentosa
por: Kaplan, Henry J., et al.
Publicado: (2017)

Metabolic rescue of cone photoreceptors in retinitis pigmentosa
por: Kaplan, Henry J., et al.
Publicado: (2021)

Loss of αA or αB-Crystallin Accelerates Photoreceptor Cell Death in a Mouse Model of P23H Autosomal Dominant Retinitis Pigmentosa
por: Wang, Tiantian, et al.
Publicado: (2021)

Identification of a rhodopsin gene mutation in a large family with autosomal dominant retinitis pigmentosa
por: Yu, Xinping, et al.
Publicado: (2016)

Genome Editing as a Treatment for the Most Prevalent Causative Genes of Autosomal Dominant Retinitis Pigmentosa
por: Diakatou, Michalitsa, et al.
Publicado: (2019)

Variant Profiling of a Large Cohort of 138 Chinese Families With Autosomal Dominant Retinitis Pigmentosa
por: Xiao, Ting, et al.
Publicado: (2021)

Autosomal dominant retinitis pigmentosa with incomplete penetrance due to an intronic mutation of the PRPF31 gene
por: Ali-Nasser, Tahleel, et al.
Publicado: (2022)

Mutation-independent gene knock-in therapy targeting 5′UTR for autosomal dominant retinitis pigmentosa
por: Hoang, Duc Anh, et al.
Publicado: (2023)

Beyond Sector Retinitis Pigmentosa: Expanding the Phenotype and Natural History of the Rhodopsin Gene Codon 106 Mutation (Gly-to-Arg) in Autosomal Dominant Retinitis Pigmentosa
por: Ballios, Brian G., et al.
Publicado: (2021)

A Novel Retinal Oscillation Mechanism in an Autosomal Dominant Photoreceptor Degeneration Mouse Model
por: Tu, Hung-Ya, et al.
Publicado: (2016)

XIAP Protection of Photoreceptors in Animal Models of Retinitis Pigmentosa
por: Leonard, Kevin C., et al.
Publicado: (2007)

Necrotic cone photoreceptor cell death in retinitis pigmentosa
por: Murakami, Y, et al.
Publicado: (2015)

Assessing Photoreceptor Structure in Retinitis Pigmentosa and Usher Syndrome
por: Sun, Lynn W., et al.
Publicado: (2016)

Cone photoreceptor dysfunction in retinitis pigmentosa revealed by optoretinography
por: Lassoued, Ayoub, et al.
Publicado: (2021)

Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa
por: Kang, Kai, et al.
Publicado: (2016)

Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa
por: Sudharsan, Raghavi, et al.
Publicado: (2017)

The Function of Drosophila USP14 in Endoplasmic Reticulum Stress and Retinal Degeneration in a Model for Autosomal Dominant Retinitis Pigmentosa
por: Park, Jung-Eun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5d2b49r0ig27ima8iaj76lh3h5