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ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y(1) Purinergic Receptor via a YPX(3)L Motif
Endocytic sorting and lysosomal degradation are integral to the regulation of G protein-coupled receptor (GPCR) function. Upon ligand binding, classical GPCRs are activated, internalized and recycled or sorted to lysosomes for degradation, a process that requires receptor ubiquitination. However, re...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907476/ https://www.ncbi.nlm.nih.gov/pubmed/27301021 http://dx.doi.org/10.1371/journal.pone.0157587 |