Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development

Hedgehog (Hh) signalling is a potent regulator of cell fate and function. While much is known about the events within a Hh-stimulated cell, far less is known about the regulation of Hh-ligand production. Drosophila Hyperplastic Discs (Hyd), a ubiquitin-protein ligase, represents one of the few non-t...

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Detalles Bibliográficos
Autores principales: Kinsella, Elaine, Dora, Natalie, Mellis, David, Lettice, Laura, Deveney, Paul, Hill, Robert, Ditzel, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907512/
https://www.ncbi.nlm.nih.gov/pubmed/27299863
http://dx.doi.org/10.1371/journal.pone.0157079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907512/
https://www.ncbi.nlm.nih.gov/pubmed/27299863
http://dx.doi.org/10.1371/journal.pone.0157079

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