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Microglia regulate hippocampal neurogenesis during chronic neurodegeneration

Neurogenesis is altered in neurodegenerative disorders, partly regulated by inflammatory factors. We have investigated whether microglia, the innate immune brain cells, regulate hippocampal neurogenesis in neurodegeneration. Using the ME7 model of prion disease we applied gain- or loss-of CSF1R func...

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Detalles Bibliográficos
Autores principales: De Lucia, Chiara, Rinchon, Adeline, Olmos-Alonso, Adrian, Riecken, Kristoffer, Fehse, Boris, Boche, Delphine, Perry, V. Hugh, Gomez-Nicola, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907582/
https://www.ncbi.nlm.nih.gov/pubmed/26541819
http://dx.doi.org/10.1016/j.bbi.2015.11.001