p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus

PAK1 inhibitors are known to markedly improve social and cognitive function in several animal models of brain disorders, including autism, but the underlying mechanisms remain elusive. We show here that disruption of PAK1 in mice suppresses inhibitory neurotransmission through an increase in tonic,...

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Detalles Bibliográficos
Autores principales: Xia, Shuting, Zhou, Zikai, Leung, Celeste, Zhu, Yuehua, Pan, Xingxiu, Qi, Junxia, Morena, Maria, Hill, Matthew N, Xie, Wei, Jia, Zhengping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907698/
https://www.ncbi.nlm.nih.gov/pubmed/27296803
http://dx.doi.org/10.7554/eLife.14653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907698/
https://www.ncbi.nlm.nih.gov/pubmed/27296803
http://dx.doi.org/10.7554/eLife.14653

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