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Phenytoin-induced isolated chronic, nocturnal dry cough
We report a 72-year-old man with a four-year history of dyscognitive seizures (with occasional secondary generalization) who developed isolated, nocturnal dry cough immediately after being started on PO phenytoin. The cough was not accompanied by any other symptom or sign as his physical exam was co...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907895/ https://www.ncbi.nlm.nih.gov/pubmed/27330990 http://dx.doi.org/10.1016/j.ebcr.2016.03.002 |
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author | Nascimento, Fábio A. Takeshita, Bruno Toshio Kowacs, Pedro A. |
author_facet | Nascimento, Fábio A. Takeshita, Bruno Toshio Kowacs, Pedro A. |
author_sort | Nascimento, Fábio A. |
collection | PubMed |
description | We report a 72-year-old man with a four-year history of dyscognitive seizures (with occasional secondary generalization) who developed isolated, nocturnal dry cough immediately after being started on PO phenytoin. The cough was not accompanied by any other symptom or sign as his physical exam was completely normal. Further investigation with chest CT and spirometry was unremarkable. This symptom persisted for six months and did not resolve until we weaned him off of phenytoin. According to the Naranjo Adverse Drug Reaction Probability Scale, his cough was classified as being probably (score + 6) related to the use of this antiepileptic drug. To our knowledge, there has been only one study that reported phenytoin-triggered cough. It described a postoperative patient who developed cough and bronchospasm after receiving IV phenytoin. By reporting our case and discussing the literature on this specific topic, we have essentially two goals. First, we intend to remind clinicians that isolated persistent cough can be an adverse reaction to phenytoin. Second, we hope to encourage further studies that will be able to elucidate the association presented herein. |
format | Online Article Text |
id | pubmed-4907895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-49078952016-06-21 Phenytoin-induced isolated chronic, nocturnal dry cough Nascimento, Fábio A. Takeshita, Bruno Toshio Kowacs, Pedro A. Epilepsy Behav Case Rep Case Report We report a 72-year-old man with a four-year history of dyscognitive seizures (with occasional secondary generalization) who developed isolated, nocturnal dry cough immediately after being started on PO phenytoin. The cough was not accompanied by any other symptom or sign as his physical exam was completely normal. Further investigation with chest CT and spirometry was unremarkable. This symptom persisted for six months and did not resolve until we weaned him off of phenytoin. According to the Naranjo Adverse Drug Reaction Probability Scale, his cough was classified as being probably (score + 6) related to the use of this antiepileptic drug. To our knowledge, there has been only one study that reported phenytoin-triggered cough. It described a postoperative patient who developed cough and bronchospasm after receiving IV phenytoin. By reporting our case and discussing the literature on this specific topic, we have essentially two goals. First, we intend to remind clinicians that isolated persistent cough can be an adverse reaction to phenytoin. Second, we hope to encourage further studies that will be able to elucidate the association presented herein. Elsevier 2016-03-16 /pmc/articles/PMC4907895/ /pubmed/27330990 http://dx.doi.org/10.1016/j.ebcr.2016.03.002 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Nascimento, Fábio A. Takeshita, Bruno Toshio Kowacs, Pedro A. Phenytoin-induced isolated chronic, nocturnal dry cough |
title | Phenytoin-induced isolated chronic, nocturnal dry cough |
title_full | Phenytoin-induced isolated chronic, nocturnal dry cough |
title_fullStr | Phenytoin-induced isolated chronic, nocturnal dry cough |
title_full_unstemmed | Phenytoin-induced isolated chronic, nocturnal dry cough |
title_short | Phenytoin-induced isolated chronic, nocturnal dry cough |
title_sort | phenytoin-induced isolated chronic, nocturnal dry cough |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907895/ https://www.ncbi.nlm.nih.gov/pubmed/27330990 http://dx.doi.org/10.1016/j.ebcr.2016.03.002 |
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