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Phenytoin-induced isolated chronic, nocturnal dry cough

We report a 72-year-old man with a four-year history of dyscognitive seizures (with occasional secondary generalization) who developed isolated, nocturnal dry cough immediately after being started on PO phenytoin. The cough was not accompanied by any other symptom or sign as his physical exam was co...

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Detalles Bibliográficos
Autores principales: Nascimento, Fábio A., Takeshita, Bruno Toshio, Kowacs, Pedro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907895/
https://www.ncbi.nlm.nih.gov/pubmed/27330990
http://dx.doi.org/10.1016/j.ebcr.2016.03.002
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author Nascimento, Fábio A.
Takeshita, Bruno Toshio
Kowacs, Pedro A.
author_facet Nascimento, Fábio A.
Takeshita, Bruno Toshio
Kowacs, Pedro A.
author_sort Nascimento, Fábio A.
collection PubMed
description We report a 72-year-old man with a four-year history of dyscognitive seizures (with occasional secondary generalization) who developed isolated, nocturnal dry cough immediately after being started on PO phenytoin. The cough was not accompanied by any other symptom or sign as his physical exam was completely normal. Further investigation with chest CT and spirometry was unremarkable. This symptom persisted for six months and did not resolve until we weaned him off of phenytoin. According to the Naranjo Adverse Drug Reaction Probability Scale, his cough was classified as being probably (score + 6) related to the use of this antiepileptic drug. To our knowledge, there has been only one study that reported phenytoin-triggered cough. It described a postoperative patient who developed cough and bronchospasm after receiving IV phenytoin. By reporting our case and discussing the literature on this specific topic, we have essentially two goals. First, we intend to remind clinicians that isolated persistent cough can be an adverse reaction to phenytoin. Second, we hope to encourage further studies that will be able to elucidate the association presented herein.
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spelling pubmed-49078952016-06-21 Phenytoin-induced isolated chronic, nocturnal dry cough Nascimento, Fábio A. Takeshita, Bruno Toshio Kowacs, Pedro A. Epilepsy Behav Case Rep Case Report We report a 72-year-old man with a four-year history of dyscognitive seizures (with occasional secondary generalization) who developed isolated, nocturnal dry cough immediately after being started on PO phenytoin. The cough was not accompanied by any other symptom or sign as his physical exam was completely normal. Further investigation with chest CT and spirometry was unremarkable. This symptom persisted for six months and did not resolve until we weaned him off of phenytoin. According to the Naranjo Adverse Drug Reaction Probability Scale, his cough was classified as being probably (score + 6) related to the use of this antiepileptic drug. To our knowledge, there has been only one study that reported phenytoin-triggered cough. It described a postoperative patient who developed cough and bronchospasm after receiving IV phenytoin. By reporting our case and discussing the literature on this specific topic, we have essentially two goals. First, we intend to remind clinicians that isolated persistent cough can be an adverse reaction to phenytoin. Second, we hope to encourage further studies that will be able to elucidate the association presented herein. Elsevier 2016-03-16 /pmc/articles/PMC4907895/ /pubmed/27330990 http://dx.doi.org/10.1016/j.ebcr.2016.03.002 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nascimento, Fábio A.
Takeshita, Bruno Toshio
Kowacs, Pedro A.
Phenytoin-induced isolated chronic, nocturnal dry cough
title Phenytoin-induced isolated chronic, nocturnal dry cough
title_full Phenytoin-induced isolated chronic, nocturnal dry cough
title_fullStr Phenytoin-induced isolated chronic, nocturnal dry cough
title_full_unstemmed Phenytoin-induced isolated chronic, nocturnal dry cough
title_short Phenytoin-induced isolated chronic, nocturnal dry cough
title_sort phenytoin-induced isolated chronic, nocturnal dry cough
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907895/
https://www.ncbi.nlm.nih.gov/pubmed/27330990
http://dx.doi.org/10.1016/j.ebcr.2016.03.002
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