Hypoxia-induced autophagy as an additional mechanism in human osteosarcoma radioresistance

Osteosarcoma (OS) responds poorly to radiotherapy, but the mechanism is unclear. We found OS tumor tissues expressed high level of protein HIF-1α, a common biological marker indicative of hypoxia. It is known that hypoxic cells are generally radioresistant because of reduced production of irradiatio...

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Detalles Bibliográficos
Autores principales: Feng, Helin, Wang, Jin, Chen, Wei, Shan, Baoen, Guo, Yin, Xu, Jianfa, Wang, Ling, Guo, Peng, Zhang, Yingze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908188/
https://www.ncbi.nlm.nih.gov/pubmed/27335774
http://dx.doi.org/10.1016/j.jbo.2016.03.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908188/
https://www.ncbi.nlm.nih.gov/pubmed/27335774
http://dx.doi.org/10.1016/j.jbo.2016.03.001

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