Increased Phospho-Keratin 8 Isoforms in Colorectal Tumors Associated with EGFR Pathway Activation and Reduced Apoptosis

Hyperphosphorylated keratin (K) 8 acts as a phosphate “sponge” for stress-activated protein kinases thereby inhibiting pro-apoptotic molecules and thus apoptosis. MAP kinase/ERK1 has increased activity in colorectal cancer (CRC) and is known to phosphorylate K8. The aims were to identify the K8 isof...

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Detalles Bibliográficos
Autores principales: Arentz, Georgia, Chataway, Tim, Condina, Mark R., Price, Timothy J., Hoffmann, Peter, Hardingham, Jennifer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908239/
https://www.ncbi.nlm.nih.gov/pubmed/27398237
http://dx.doi.org/10.5402/2012/706545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908239/
https://www.ncbi.nlm.nih.gov/pubmed/27398237
http://dx.doi.org/10.5402/2012/706545

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