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RCK: accurate and efficient inference of sequence- and structure-based protein–RNA binding models from RNAcompete data
Motivation: Protein–RNA interactions, which play vital roles in many processes, are mediated through both RNA sequence and structure. CLIP-based methods, which measure protein–RNA binding in vivo, suffer from experimental noise and systematic biases, whereas in vitro experiments capture a clearer si...
Autores principales: | Orenstein, Yaron, Wang, Yuhao, Berger, Bonnie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908343/ https://www.ncbi.nlm.nih.gov/pubmed/27307637 http://dx.doi.org/10.1093/bioinformatics/btw259 |
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