A humanized anti-DLL4 antibody promotes dysfunctional angiogenesis and inhibits breast tumor growth

Blockage of Delta-like 4 (DLL4)-directed Notch signaling induces excessive tip cell formation and endothelial proliferation resulting in dysfunctional angiogenesis in tumors. MMGZ01, as a murine anti-human DLL4 monoclonal antibody, specifically binds to human DLL4 and blocks Notch pathway. Here, the...

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Detalles Bibliográficos
Autores principales: Jia, Xuelian, Wang, Wenyi, Xu, Zhuobin, Wang, Shijing, Wang, Tong, Wang, Min, Wu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908374/
https://www.ncbi.nlm.nih.gov/pubmed/27301650
http://dx.doi.org/10.1038/srep27985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908374/
https://www.ncbi.nlm.nih.gov/pubmed/27301650
http://dx.doi.org/10.1038/srep27985

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