Conformational flexibility related to enzyme activity: evidence for a dynamic active-site gatekeeper function of Tyr(215) in Aerococcus viridans lactate oxidase

L-Lactate oxidase (LOX) belongs to a large family of flavoenzymes that catalyze oxidation of α-hydroxy acids. How in these enzymes the protein structure controls reactivity presents an important but elusive problem. LOX contains a prominent tyrosine in the substrate binding pocket (Tyr(215) in Aeroc...

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Detalles Bibliográficos
Autores principales: Stoisser, Thomas, Brunsteiner, Michael, Wilson, David K., Nidetzky, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908395/
https://www.ncbi.nlm.nih.gov/pubmed/27302031
http://dx.doi.org/10.1038/srep27892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908395/
https://www.ncbi.nlm.nih.gov/pubmed/27302031
http://dx.doi.org/10.1038/srep27892

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