The cleaved FAS ligand activates the Na(+)/H(+) exchanger NHE1 through Akt/ROCK1 to stimulate cell motility

Transmembrane CD95L (Fas ligand) can be cleaved to release a promigratory soluble ligand, cl-CD95L, which can contribute to chronic inflammation and cancer cell dissemination. The motility signaling pathway elicited by cl-CD95L remains poorly defined. Here, we show that in the presence of cl-CD95L,...

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Detalles Bibliográficos
Autores principales: Monet, Michael, Poët, Mallorie, Tauzin, Sébastien, Fouqué, Amélie, Cophignon, Auréa, Lagadic-Gossmann, Dominique, Vacher, Pierre, Legembre, Patrick, Counillon, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908414/
https://www.ncbi.nlm.nih.gov/pubmed/27302366
http://dx.doi.org/10.1038/srep28008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908414/
https://www.ncbi.nlm.nih.gov/pubmed/27302366
http://dx.doi.org/10.1038/srep28008

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