Unexpected severe consequences of Pikfyve deletion by aP2‐ or Aq‐promoter‐driven Cre expression for glucose homeostasis and mammary gland development

Systemic deficiency of PIKfyve, the evolutionarily conserved phosphoinositide kinase synthesizing cellular PtdIns5P and PtdIns(3,5)P(2) and implicated in insulin signaling, causes early embryonic death in mice. In contrast, mice with muscle‐specific Pikfyve disruption have normal lifespan but exhibi...

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Detalles Bibliográficos
Autores principales: Ikonomov, Ognian C., Sbrissa, Diego, Delvecchio, Khortnal, A. Rillema, James, Shisheva, Assia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908490/
https://www.ncbi.nlm.nih.gov/pubmed/27273882
http://dx.doi.org/10.14814/phy2.12812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908490/
https://www.ncbi.nlm.nih.gov/pubmed/27273882
http://dx.doi.org/10.14814/phy2.12812

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