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Unexpected severe consequences of Pikfyve deletion by aP2‐ or Aq‐promoter‐driven Cre expression for glucose homeostasis and mammary gland development
Systemic deficiency of PIKfyve, the evolutionarily conserved phosphoinositide kinase synthesizing cellular PtdIns5P and PtdIns(3,5)P(2) and implicated in insulin signaling, causes early embryonic death in mice. In contrast, mice with muscle‐specific Pikfyve disruption have normal lifespan but exhibi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908490/ https://www.ncbi.nlm.nih.gov/pubmed/27273882 http://dx.doi.org/10.14814/phy2.12812 |