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Two ortho­rhom­bic polymorphs of hydro­morphone

Conditions to obtain two polymorphic forms by crystallization from solution were determined for the analgesic drug hydro­morphone [C(17)H(19)NO(3); systematic name: (4R,4aR,7aR,12bS)-9-hy­droxy-3-methyl-1,2,4,4a,5,6,7a,13-octa­hydro-4,12-methano­benzofuro[3,2-e]iso­quinolin-7-one]. These two crystal...

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Detalles Bibliográficos
Autores principales: Mazurek, Jaroslaw, Hoffmann, Marcel, Fernandez Casares, Ana, Cox, D. Phillip, Minardi, Mathew D., Sasine, Josh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908523/
https://www.ncbi.nlm.nih.gov/pubmed/27308029
http://dx.doi.org/10.1107/S2056989016006563