Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo

Octamer-binding transcription factor 4 (OCT-4) is an important marker of cellular de-differentiation that can be induced by environmental stressors, such as acidity. Here we demonstrate that chronic acidic stress in solid tumors induced OCT-4 expression in fibroblasts and other stromal cells in four...

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Detalles Bibliográficos
Autores principales: Som, Avik, Bloch, Sharon, Ippolito, Joseph E., Achilefu, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908587/
https://www.ncbi.nlm.nih.gov/pubmed/27302093
http://dx.doi.org/10.1038/srep27803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908587/
https://www.ncbi.nlm.nih.gov/pubmed/27302093
http://dx.doi.org/10.1038/srep27803

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