Targeting epigenetic pathways in acute myeloid leukemia and myelodysplastic syndrome: a systematic review of hypomethylating agents trials

BACKGROUND: Aberrant DNA methylation has been identified as a key molecular event regulating the pathogenesis of myelodysplastic syndromes (MDS); myeloid neoplasms with an inherent risk of transformation to acute myeloid leukemia (AML). Based on the above findings, DNA hypomethylating agents (HMA) h...

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Detalles Bibliográficos
Autores principales: Yun, Seongseok, Vincelette, Nicole D., Abraham, Ivo, Robertson, Keith D., Fernandez-Zapico, Martin E., Patnaik, Mrinal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908810/
https://www.ncbi.nlm.nih.gov/pubmed/27307795
http://dx.doi.org/10.1186/s13148-016-0233-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908810/
https://www.ncbi.nlm.nih.gov/pubmed/27307795
http://dx.doi.org/10.1186/s13148-016-0233-2

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