Cryo-EM reveals a novel octameric integrase structure for β-retroviral intasome function

Retroviral integrase (IN) catalyzes the integration of viral DNA (vDNA) into host target (tDNA), which is an essential step in the lifecycle of all retroviruses(1). Prior structural characterization of IN-vDNA complexes, or intasomes, from the spumavirus prototype foamy virus (PFV) revealed a functi...

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Detalles Bibliográficos
Autores principales: Ballandras-Colas, Allison, Brown, Monica, Cook, Nicola J., Dewdney, Tamaria G., Demeler, Borries, Cherepanov, Peter, Lyumkis, Dmitry, Engelman, Alan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908968/
https://www.ncbi.nlm.nih.gov/pubmed/26887496
http://dx.doi.org/10.1038/nature16955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908968/
https://www.ncbi.nlm.nih.gov/pubmed/26887496
http://dx.doi.org/10.1038/nature16955

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