Microglia-specific targeting by novel capsid-modified AAV6 vectors

Recombinant adeno-associated viruses (rAAV) have been widely used in gene therapy applications for central nervous system diseases. Though rAAV can efficiently target neurons and astrocytes in mouse brains, microglia, the immune cells of the brain, are refractile to rAAV. To identify AAV capsids wit...

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Dettagli Bibliografici
Autori principali: Rosario, Awilda M, Cruz, Pedro E, Ceballos-Diaz, Carolina, Strickland, Michael R, Siemienski, Zoe, Pardo, Meghan, Schob, Keri-Lyn, Li, Andrew, Aslanidi, George V, Srivastava, Arun, Golde, Todd E, Chakrabarty, Paramita
Natura: Online Articolo testo
Lingua:English
Pubblicazione: Nature Publishing Group 2016
Soggetti:
Article
Accesso online:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909093/
https://www.ncbi.nlm.nih.gov/pubmed/27308302
http://dx.doi.org/10.1038/mtm.2016.26

Accesso online

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909093/
https://www.ncbi.nlm.nih.gov/pubmed/27308302
http://dx.doi.org/10.1038/mtm.2016.26

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