Microglia-specific targeting by novel capsid-modified AAV6 vectors

Recombinant adeno-associated viruses (rAAV) have been widely used in gene therapy applications for central nervous system diseases. Though rAAV can efficiently target neurons and astrocytes in mouse brains, microglia, the immune cells of the brain, are refractile to rAAV. To identify AAV capsids wit...

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Detalles Bibliográficos
Autores principales: Rosario, Awilda M, Cruz, Pedro E, Ceballos-Diaz, Carolina, Strickland, Michael R, Siemienski, Zoe, Pardo, Meghan, Schob, Keri-Lyn, Li, Andrew, Aslanidi, George V, Srivastava, Arun, Golde, Todd E, Chakrabarty, Paramita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909093/
https://www.ncbi.nlm.nih.gov/pubmed/27308302
http://dx.doi.org/10.1038/mtm.2016.26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909093/
https://www.ncbi.nlm.nih.gov/pubmed/27308302
http://dx.doi.org/10.1038/mtm.2016.26

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