PGC1α-dependent NAD biosynthesis links oxidative metabolism to renal protection

The energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischemia. Indeed, acute kidney injury (AKI) affects 3% of all hospitalized patients.(1,2) Here we show that the mitochondrial biogenesis regulator, PGC1α,(3,4)...

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Detalles Bibliográficos
Autores principales: Tran, Mei T., Zsengeller, Zsuzsanna K., Berg, Anders H., Khankin, Eliyahu V., Bhasin, Manoj K., Kim, Wondong, Clish, Clary B., Stillman, Isaac E., Karumanchi, S. Ananth, Rhee, Eugene P., Parikh, Samir M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909121/
https://www.ncbi.nlm.nih.gov/pubmed/26982719
http://dx.doi.org/10.1038/nature17184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909121/
https://www.ncbi.nlm.nih.gov/pubmed/26982719
http://dx.doi.org/10.1038/nature17184

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